Adam Frost, PhD, MD

Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.

Science (New York, N.Y.)

Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P

CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides.

Science (New York, N.Y.)

Kostova KK, Hickey KL, Osuna BA, Hussmann JA, Frost A, Weinberg DE, Weissman JS

In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing.

eLife

Osuna BA, Howard CJ, Kc S, Frost A, Weinberg DE

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.

Proceedings of the National Academy of Sciences of the United States of America

Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A

Membrane fission by dynamin: what we know and what we need to know.

The EMBO journal

Antonny B, Burd C, De Camilli P, Chen E, Daumke O, Faelber K, Ford M, Frolov VA, Frost A, Hinshaw JE, Kirchhausen T, Kozlov MM, Lenz M, Low HH, McMahon H, Merrifield C, Pollard TD, Robinson PJ, Roux A, Schmid S

A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP.

The EMBO journal

Hwang J, Ribbens D, Raychaudhuri S, Cairns L, Gu H, Frost A, Urban S, Espenshade PJ

Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex.

Nature structural & molecular biology

Heider MR, Gu M, Duffy CM, Mirza AM, Marcotte LL, Walls AC, Farrall N, Hakhverdyan Z, Field MC, Rout MP, Frost A, Munson M

Structure and membrane remodeling activity of ESCRT-III helical polymers.

Science (New York, N.Y.)

McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI, Frost A

Structural and functional studies of membrane remodeling machines.

Methods in cell biology

Kalia R, Talledge N, Frost A

Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains.

Science (New York, N.Y.)

Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost A

Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission.

Proceedings of the National Academy of Sciences of the United States of America

Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw JM

A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress.

Cell

Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman JS