Dave Agard, PhD

+1 415 476-2521

Our research is focused on elucidating the mechanism of Hsp90 chaperone function and its role in human disease, microtubule nucleation & centrosome structure, and the structure and cell biology of phage-encoded tubulins. Accompanying this is an effort to develop new technologies for high-resolution cryoEM and fluorescence light microscopy.

Featured Publications: 

The Structural Asymmetry of Mitochondrial Hsp90 (Trap1) Determines Fine Tuning of Functional Dynamics.

Journal of chemical theory and computation

Moroni E, Agard DA, Colombo G

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase.

Science (New York, N.Y.)

Verba KA, Wang RY, Arakawa A, Liu Y, Shirouzu M, Yokoyama S, Agard DA

A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity.


Partridge JR, Lavery LA, Elnatan D, Naber N, Cooke R, Agard DA