Professor
M_Biochemistry and Biophysics
+1 415 476-5143
Our research is focused on elucidating the mechanism of Hsp90 chaperone function and its role in human disease, microtubule nucleation & centrosome structure, and the structure and cell biology of phage-encoded tubulins. Accompanying this is an effort to develop new technologies for high-resolution cryoEM and fluorescence light microscopy.
Publications
Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity.
The Journal of biological chemistry
The Structural Asymmetry of Mitochondrial Hsp90 (Trap1) Determines Fine Tuning of Functional Dynamics.
Journal of chemical theory and computation
Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase.
Science (New York, N.Y.)