2024

• Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. Chio US, Palovcak E, Smith AAA, Autzen H, Muñoz EN, Yu Z, Wang F, Agard DA, Armache JP, Narlikar GJ, Cheng Y. Nat Commun. 2024 Mar 12;15(1):2225. https://pubmed.ncbi.nlm.nih.gov/38472177/
• Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation. Trenker R, Diwanji D, Bingham T, Verba KA, Jura N. Elife. 2024 Mar 18:12:RP92873. https://pubmed.ncbi.nlm.nih.gov/38498590/
• Structural basis of prostaglandin efflux by MRP4. Pourmal S, Green E, Bajaj R, Chemmama IE, Knudsen GM, Gupta M, Sali A, Cheng Y, Craik CS, Kroetz DL, Stroud RM. Nat Struct Mol Biol. 2024 Apr;31(4):621-632. https://pubmed.ncbi.nlm.nih.gov/38216659/
• GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter JF, Dror RO, Evers AS, Mukhopadhyay S, Manglik A. Nat Struct Mol Biol. 2024 Apr;31(4):667-677. https://pubmed.ncbi.nlm.nih.gov/38326651/
• Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4. Zhou X, Kong S, Maker A, Remesh SG, Leung KK, Verba KA, Wells JA. Nat Chem Biol. 2024 Jun;20(6):742-750. https://pubmed.ncbi.nlm.nih.gov/38308046/
• Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome. Zhao B, Cao Z, Zheng Y, Nguyen P, Bowen A, Edwards RH, Stroud RM, Zhou Y, Van Lookeren Campagne M, Li F. Nat Commun. 2024 Jun 25;15(1):5388. https://pubmed.ncbi.nlm.nih.gov/38918376/
• Poc1 bridges basal body inner junctions to promote triplet microtubule integrity and connections. Ruehle MD, Li S, Agard DA, Pearson CG. J Cell Biol. 2024 Aug 5;223(8):e202311104. https://pubmed.ncbi.nlm.nih.gov/38743010/
• High-resolution single-particle imaging at 100-200 keV with the Gatan Alpine direct electron detector. Chan LM, Courteau BJ, Maker A, Wu M, Basanta B, Mehmood H, Bulkley D, Joyce D, Lee BC, Mick S, Czarnik C, Gulati S, Lander GC, Verba KA. J Struct Biol. 2024 Sep;216(3):108108. https://pubmed.ncbi.nlm.nih.gov/38944401/
• Structural basis of TRPV1 modulation by endogenous bioactive lipids. Arnold WR, Mancino A, Moss FR 3rd, Frost A, Julius D, Cheng Y. Nat Struct Mol Biol. 2024 Sep;31(9):1377-1385. https://pubmed.ncbi.nlm.nih.gov/38698206/
• A systematic search for RNA structural switches across the human transcriptome. Khoroshkin M, Asarnow D, Zhou S, Navickas A, Winters A, Goudreau J, Zhou SK, Yu J, Palka C, Fish L, Borah A, Yousefi K, Carpenter C, Ansel KM, Cheng Y, Gilbert LA, Goodarzi H. Nat Methods. 2024 Sep;21(9):1634-1645. https://pubmed.ncbi.nlm.nih.gov/39014073/
• Structural basis of μ-opioid receptor targeting by a nanobody antagonist. Yu J, Kumar A, Zhang X, Martin C, Van Holsbeeck K, Raia P, Koehl A, Laeremans T, Steyaert J, Manglik A, Ballet S, Boland A, Stoeber M. Nat Commun. 2024 Oct 9;15(1):8687. https://pubmed.ncbi.nlm.nih.gov/39384768/
• Dynamic allostery drives autocrine and paracrine TGF-β signaling. Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y. Cell. 2024 Oct 31;187(22):6200-6219.e23. https://pubmed.ncbi.nlm.nih.gov/39288764/
• Engineered odorant receptors illuminate the basis of odour discrimination. de March CA, Ma N, Billesbølle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H. Nature. 2024 Oct 30. https://pubmed.ncbi.nlm.nih.gov/39478229/