
Assistant Professor
M_CMP (Cellular Molecular Pha)
+1 415 353-3822
Publications
Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy.
Science advances
The Chlamydia effector Dre1 binds dynactin to reposition host organelles during infection.
Cell reports
Structures of the PI3Kα/KRas complex on lipid bilayers reveal the molecular mechanism of PI3Kα activation.
bioRxiv : the preprint server for biology
Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response.
bioRxiv : the preprint server for biology
High-resolution single-particle imaging at 100-200 keV with the Gatan Alpine direct electron detector.
Journal of structural biology
High-resolution single-particle imaging at 100-200 keV with the Gatan Alpine direct electron detector.
bioRxiv : the preprint server for biology
Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4.
Nature chemical biology
Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation.
bioRxiv : the preprint server for biology
Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3.
Nature communications
Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps.
Structure (London, England : 1993)
Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3.
Nature communications
Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps.
bioRxiv : the preprint server for biology
An effective strategy for ligand-mediated pulldown of the HER2/HER3/NRG1β heterocomplex and cryo-EM structure determination at low sample concentrations.
Methods in enzymology
Efficient expression, purification, and visualization by cryo-EM of unliganded near full-length HER3.
Methods in enzymology
Author Correction: Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface.
Nature
Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant.
bioRxiv : the preprint server for biology
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
Research square
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
bioRxiv : the preprint server for biology
Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM.
Journal of structural biology
Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.
Cancer research
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Science (New York, N.Y.)
Development of a structure-analysis pipeline using multiple-solvent crystal structures of barrier-to-autointegration factor.
Acta crystallographica. Section D, Structural biology
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
bioRxiv : the preprint server for biology
Protein Expression and Purification of the Hsp90-Cdc37-Cdk4 Kinase Complex from Saccharomyces cerevisiae.
Bio-protocol
How Hsp90 and Cdc37 Lubricate Kinase Molecular Switches.
Trends in biochemical sciences
MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy.
Nature methods
Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase.
Science (New York, N.Y.)
Cross-monomer substrate contacts reposition the Hsp90 N-terminal domain and prime the chaperone activity.
Journal of molecular biology